个人简介：

从事菌群宏基因组学及抗性组学，空气微生物组学等研究， 近五年在Journal of Antimicrobial Chemotherapy，Applied and Environmental Microbiology、Computational and Structural Biotechnology Journal，American Journal of Respiratory and Critical Care Medicine 等SCI杂志发表研究论文10篇。

教育背景：

2012/8-2017/2, 新加坡南洋理工大学, 环境与生命科学工程研究中心, 博士

2008/8-2012/5, 新加坡南洋理工大学, 化学与医药工程学院, 学士

工作经历：

2020/6-至今   ，江南捕鱼（中国官网）有限公司,，医学院，研究助理教授

2020/3-2020/5，江南捕鱼（中国官网）有限公司,，医学院，助理研究员

2017/4-2020/2, 新加坡南洋理工大学, 环境与生命科学工程研究中心, Research Fellow

发表论文：

1. Jiuxin Qu; Zhao Cai Z ; Xiangke Duan; Han Zhang; Hang Cheng; Shuhong Han; Kaiwei Yu; Zhaofan g Jiang; Yingdan Zhang; Yang Liu; Fang Bai; Yingxia Liu; Lei Liu; Liang Yang ; Pseudomonas aerugi nosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients, Cell & Bioscience, 2022, 12(1): 14

2. Jiuxin Qu; Zhao Cai Z ; Yumei Liu; Xiangke Duan; Shuhong Han; Jihong Liu; Yuao Zhu; Zhaofang Jiang; Yingdan Zhang; Chao Zhuo; Yang Liu; Yingxia Liu; Lei Liu; Liang Yang ; Persistent bacteria l coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chroni c colonizer, Frontiers in Cellular and Infection Microbiology, 2021, 11: 641920 

3. Zhenpeng Li; Zhao Cai Z ; Zeqiong Cai; Yanhong Zhang; Tongtong Fu; Yongxin Jin; Zhihui Cheng ; Shouguang Jin; Weihui Wu; Liang Yang; Fang Bai ; Molecular genetic analysis of an XDR Pseudomon as aeruginosa ST664 clone carrying multiple conjugal plasmids, Journal of Antimicrobial Chemother apy, 2020, 75(6): 1443-1452

4. Zhao Cai Z ; Yang Liu; Yicai Chen; Joey Kuok Hoong Yam; Su Chuen Chew; Song Lin Chua; Ke Wan g; Michael Givskov; Liang Yang ; RpoN Regulates Virulence Factors of Pseudomonas aeruginosa via M odulating the PqsR Quorum Sensing Regulator, International Journal of Molecular Sciences, 2015, 16: 28311-28319

5. Guohui Xiao; Zhao Cai Z ; Qinglong Guo; Taosheng Ye; Yimin Tang; Peikun Guan; Juanjuan Zhang ; Min Ou; Xiangdong Fu; Lili Ren; Minfei Yu; Zhaoqin Wang; Lei Liu; Liang Yang; Guoliang Zhang ; Insights into the Unique Lung Microbiota Profile of Pulmonary Tuberculosis Patients Using Metagen omic Next-Generation Sequencing, Microbiology Spectrum, 2022, 10(1): e0190121
   

6. Peiyan Zhang#,Zhao Cai#,Weibo Wu,Ling Peng,Yinfeng Li,Chuming Chen,Li Chen,Jianming Li,Mengli Cao,Shiyan Feng,Xiao Jiang, Jing Yuan, Yingxia Liu, Liang Yang†, Fuxiang Wang† The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: A case report，BMC Infectious Diseases, DOI : 10.1186/s12879-020-05045-z

7.  Zhenpeng Li#, Zhao Cai#, Zeqiong Cai, Yanhong Zhang, Tongtong Fu, Yongxin Jin, Zhihui Cheng, Shouguang Ji, Weihui Wu, Liang Yang†, Fang Bai† (2020) Extensively Drug-Resistant Molecular Genetic Analysis of An XDR-Pseudomonas aeruginosa ST664 Clone Carrying Multiple Conjugal Plasmids, Journal of Antimicrobial Chemotherapy

8. Tingting Wang#, Zhao Cai#, Xiaolong Shao, Weitong Zhang, Yingpeng Xie, Yingchao Zhang, Canfeng Hua, Stephan C. Schuster, Liang Yang, Xin Deng (2019) The Pleiotropic Effects of c-di-GMP Content in Pseudomonas syringae, Applied and Environmental Microbiology. 2019 Mar 8. pii: AEM.00152-19. doi: 10.1128/AEM.00152-19

9. Fang Bai#, Zhao Cai#, Liang Yang (2019) Recent progress in experimental and human disease-associated multi-species biofilms, Review, Computational and Structural Biotechnology Journal, 2019, 17, 1234-1244

10. Micheál Mac Aogáin#, Kenny J. X. Lau#, Cai Zhao, Jayanth Kumar Narayana, Rikky W.Purbojati, Daniela I. Drautz-Moses, Nicolas E. Gaultier, Tavleen K. Jaggi, Pei Yee Tiew,
    Thun How Ong, Mariko Siyue Koh, Albert Lim Yick Hou, John A. Abisheganaden, Krasimira Tsaneva-Atanasova, Stephan C. Schuster, Sanjay H. Chotirmall. (2020) Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease, American Journal of Respiratory and Critical Care Medicine, doi: 10.1164/rccm.201911-2202OC. [Epub ahead of print]

11. Yaqin Song, Chun Yang, Gukui Chen, Yixi Zhang, Zijing Seng, Zhao Cai, Chao Zhang, Liang Yang, Jianhua Gan, and Haihua Liang (2019) Molecular insights into the master regulator CysB mediated bacterial virulence in Pseudomonas aeruginosa. Molecular Micorbiology, doi: 10.1111/mmi.14200

12. Yingying Cheng, Joey Kuok Hoong Yam, Zhao Cai, Yichen Ding, Lian-Hui Zhang, Yinyue Deng, Liang Yang (2018) Population dynamics and transcriptomic responses of Pseudomonas aeruginosa in a complex laboratory microbial community, npj Biofilms and Microbiomes doi: 10.1038/s41522-018-0076-z

13. Lin Chua S, Liu Y, Li Y, Jun Ting H, Kohli GS, Cai Z, Suwanchaikasem P, Kau Kit Goh K,Pin Ng S, Tolker-Nielsen T, Yang L, Givskov M. (2017) Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa. Front Cell Infect Microbiol. 2017 Oct;7:451. doi: 10.3389/fcimb.2017.00451

14. Song Lin Chua, Yichen Ding, Yang Liu, Zhao Cai, Jianuan Zhou, Sanjay Swarup, Daniela I.Drautz-Moses, Stephan Christoph Schuster, Staffan Kjelleberg, Michael Givskov and Liang Yang (2016) Reactive oxygen species drive evolution of pro-biofilm variants in pathogens by modulating cyclic-di-GMP levels; Open Biology, 6: 160162

15. Victor Bochuan Wang, Song-Lin Chua, Zhao Cai, Krishnakumar Sivakumar, Qichun Zhang,Staffan Kjelleberg, Bin Cao, Say Chye Joachim Loo, Liang Yang (2014) A stable synergistic microbial consortium for simultaneous azo dye removal and bioelectricity generation; Bioresource Technology, 155 (2014) 71–76

16. Yang-Chun Yong, Zhao Cai, Yang-Yang Yu, Peng Chen , Rongrong Jiang , Bin Cao , Jian-Zhong Sun, Jing-Yuan Wang, Hao Song (2013) Increase of riboflavin biosynthesis underlies enhancement of extracellular electron transfer of Shewanella in alkaline microbial fuel cells; Bioresource Technology, 130 (2013) 763–768

17. Yang-Chun Yong, Jing-Xian Wang, Zhao Cai and Jian-Zhong Sun. (2013) Chapter 5 Quorum sensing for clean environment and green bioenergy. Advances in Environmental Research. Volume 28. pp. 129-148. ISBN: 978-1-62417-738-5.（Book chapter）