个人简介：

洪鑫博士是江南捕鱼（中国官网）有限公司,医学院生物化学系助理教授(Tenure-track A/P)，博士生导师，于2013年博士毕业于新加坡国立大学，2014-2020年博士后期间在哈佛医学院／霍华德医学研究中心 (HHMI) 致力于癌症转移生物学机制和循环肿瘤细胞（CTC）液体活检技术的研发，相关成果发表在 Cell、 Cancer Discovery、 PNAS、 EMBO Journal、 Genes & Development 等国际著名期刊，引用超过1400次 （H-index = 19）,并获得了多个国际和国内奖项和荣誉，包括新加坡国立大学最佳毕业生奖（Lijen Industrial Development Award, NUS), 新加坡科研局青年基金（A*STAR JCO early career development award）以及美国癌症协会 (AACR) 的青年学者奖项 （AACR Scholar-In-Training Award)。自2020年8月组建团队以来，本课题组获批主持/承担国家级项目4项，包括国家基金委外国优秀青年学者项目、面上/青年项目、以及省部级重点研发和面上项目等共10余项科研基金，拥有3项国际专利。

教育背景：

2008 – 2013              博士，生物医学，新加坡国立大学, 新加坡

2002 – 2006              荣誉学士，生物学，新加坡国立大学，新加坡

工作经历：

08/2020 – 至今           助理教授，博士生导师，江南捕鱼（中国官网）有限公司,医学院，中国

07/2014 – 05/2020     HHMI 博士后，麻省总医院癌症中心／哈佛医学院，美国

04/2013 – 06/2014     过渡博士后, 新加坡科研局(A*STAR)／新加坡国立大学，新加坡

获奖情况及荣誉：

2020            美国癌症协会(AACR) Scholar-In-Training Award，美国

2013            新加坡科研局（A*STAR)青年基金（JCO Career Development Award), 新加坡

2007-2010   研究生奖学金（Junior Research Fellowship),淡马锡生命科学实验室(TLL),新加坡

2006             新加坡国立大学本科最佳毕业设计奖(LiJen Industrial Development Medal), 新加坡

2002-2006   教育部留学生奖学金（本科），新加坡教育部

研究领域：

癌症转移机制，液体活检术，循环肿瘤细胞 (CTC)：

1. 建立基于CTC的癌转移动物模型（CDX)，研究CTC介导的癌远程转移分子生物学机制

2. 结合新一代微流控CTC芯片技术和单细胞组学绘制CTC转移和增殖的癌细胞进化图谱

3. 液体活检技术开发

4. 开发和筛选抑制CTC远程转移的小分子药物

学术任职：

Theranostics  (客座编辑，2021-至今)

BMC Cancer （副主编/编委，2022-至今）

Frontiers In Oncology （编委，2022-至今）

Frontiers In Genetics （副主编/编委，2021-至今）

Cancer Drug Resistance（青年编委，2022-至今）

发表论文：

First/Co-first author papers

1. Xin Hong*, Ryan J. Sullivan*, Mark Kalinich, Tanya Todorova Kwan, Shiwei Pan, Joseph A. LiCausi, John D. Milner, Linda T. Nieman, Ben S. Wittner, Uyen Ho, Tianqi Chen, Ravi Kapur, Don Lawrence, Keith T. Flaherty, Lecia V. Sequist, Sridhar Ramaswamy, David T. Miyamoto, Michael Lawrence, Anita Giobbie- Hurder, Mehmet Toner, Kurt J. Isselbacher, Shyamala Maheswaran†, and Daniel A. Haber†. Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy. PNAS. 115 (10) 2467-72(2018). (*Equal contributions; † co-corresponding authors)
2. Xin Hong*, Nguyen Thanh Hung*, QingFeng Chen, Rui Zhang, Zandra, Hagman, Mathijs Voorhoeve and Stephen M Cohen. Opposing activities of the Ras and Hippo pathways in cellular transformation converge on regulation of YAP turnover. EMBO J. 33(21):2447-57(2014). (*Equal contributions)
3. Nguyen Thanh Hung*, Xin Hong*, Sam Tan, Qingfeng Chen, Lifang Chan, Marc Fivaz, Stephen M Cohen and Mathijs Voorhoeve. Viral small T oncoproteins transform cells by alleviating hippo-pathway-mediated inhibition of the YAP proto-oncogene. Cell Reports. 7;8(3):707-13 (2014). (*Equal contributions)
4. Héctor Herranz*, Xin Hong*, Nguyen Thanh Hung, P. Mathijs Voorhoeve and Stephen M Cohen. Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes & Development. 26(14):1602-11 (2012). (* Equal contributions)
5. Xin Hong*, Molly Hammell*, Victor Ambros, and Stephen M Cohen. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. PNAS. 106(35): 15085–90 (2009). (*Equal contributions)

Coauthor papers:
6. Jon F Edd, Avanish Mishra, Taronish D Dubash, Stefan Herrera, Ridhwan Mohammad, E Kendall Williams, Xin Hong, Baris R Mutlu, John R Walsh, Fernanda Machado de Carvalho, Berent Aldikacti, Linda T Nieman, Shannon L Stott, Ravi Kapur, Shyamala Maheswaran, Daniel A Haber, Mehmet Toner. Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes. Lab on a Chip 20 (3): 558-567 (2020).
7. Carlos Alberto Aya-Bonilla, Michael Morici, Xin Hong, Ashleigh Cavell McEvoy, Ryan Joseph Sullivan, James Freeman, Leslie Calapre, Muhammad Adnan Khattak, Tarek Meniawy, Michael Millward, Mel Ziman, Elin Solomonovna Gray. Molecular heterogeneity of Melanoma Circulating Tumour Cells. British Journal of Cancer 122) (7): 1059-1067 (2020).
8. Chuan Yan*, Dalton C Brunson*, Qin Tang*, Daniel Do*, Nicolae A Iftimia, John C Moore, Madeline N Hayes, Alessandra M Welker, Elaine G Garcia, Taronish D Dubash, Xin Hong, Benjamin J Drapkin, David T Myers, Sarah Phat, Angela Volorio, Dieuwke L Marvin, Matteo Ligorio, Lyle Dershowitz, Karin M McCarthy, Murat N Karabacak, Jonathan A Fletcher, Dennis C Sgroi, John A Iafrate, Shyamala Maheswaran, Nick J Dyson, Daniel A Haber, John F Rawls, David M Langenau**. Visualizing engrafted human cancer and therapy responses in immunodeficient zebrafish. Cell 177(7):1903-1914 (2019). (*Equal contributions).
9. David T. Miyamoto*, Richard J. Lee*, Mark Kalinich, Joseph LiCausi, Yu Zheng, Tianqi Chen, John D. Milner, Erin Emmons, Uyen Ho, Katherine Broderick, Ben S. Wittner, Erin Silva, Sarah Javaid, Tanya Todorova Kwan, Xin Hong, Douglas M. Dahl, Jason A. Efstathiou, Matthew R. Smith, Lecia V. Sequist, Ravi Kapur, Chin-Lee Wu, Shannon L. Stott, David T. Ting, Sridhar Ramaswamy, Anita Giobbie-Hurder, Mehmet Toner, Shyamala Maheswaran**, Daniel A. Haber**. An RNA-based digital circulating tumor cell signature is predictive of drug response and early dissemination in prostate cancer. Cancer Discovery 8 (3): 288-303 (2018). (*Equal contributions; ** co-corresponding authors).
10. Tanya T. Kwan*, Aditya Bardia*, Laura M. Spring, Anita Giobbie-Hurder, Mark Kalinich, Taronish Dubash, Tilak Sundaresan, Xin Hong, Joseph A. LiCausi, Uyen Ho, Erin J. Silva, Ben S. Wittner, Lecia V. Sequist, Ravi Kapur, David T. Miyamoto, Mehmet Toner, Daniel A. Haber**, Shyamala Maheswaran**. A digital RNA signature of Circulating Tumor Cells to predict early response in metastatic and localized breast cancer. Cancer Discovery 8(10):1286-1299 (2018). (*Equal contributions; ** co-corresponding authors).
11. Mark Kalinich*, Irun Bhan*, Tanya T. Kwan, David T. Miyamoto, Sarah Javaid, Joseph A. LiCausi, John D. Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A. Weitz, Lecia V. Sequist, David P. Ryan, Raymond T. Chung, Andrew X. Zhu, Kurt J. Isselbacher, David T. Ting, Mehmet Toner, Shyamala Maheswaran†, and Daniel A. Haber†. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. PNAS. 114(5):1123-1128 (2017). (*Equal contributions; † co-corresponding authors).
12. Hung Thanh Nguyen, Diana Andrejeva, Rajat Gupta, Chunaram Choudhary, Xin Hong, Pieter JA Eichhorn, Anand C Loya, Stephen M Cohen. Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover. Cell Discovery. 2: (1):1-13 (2016).
13. Wanzhong Ge, Qiannan Deng, Ting Guo, Xin Hong, Jan-Michael Kugler, Xiaohang Yang and Stephen M. Cohen. Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA. Genetics. 200(1):255-65 (2015).
14. Héctor Herranz, Xin Hong, Stephen M. Cohen. Mutual Repression by Bantam miRNA and Capicua Links the EGFR/MAPK and Hippo Pathways in Growth Control. Current Biology. 22(8): 651–7 (2012).
15. Isabelle Becam*, Neus Rafel*, Xin Hong, Stephen M Cohen and Marco Milán. Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing. Development. 138(17): 3781-9 (2011). (* Equal contributions).
16. Hector Herranz, Xin Hong, Lidia Perez, Ana Ferreira, Daniel Olivieri, Stephen M Cohen and Marco Milan. The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing. EMBO J. 29(10): 1688– 98 (2010).
17. Zhen Zhi Tang, Ping Liao, Guang Li, Feng Li Jiang, Dejie Yu, Xin Hong, TanFong Yong, Gregory Tan, Songqing Lu, Jing Wang and Tuck Wah Soong. Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta. 1783(1):118-30 (2008).
18. Zhen Zhi Tang, Xin Hong, Jing Wang, and Tuck Wah Soong. Signature Combinatorial Splicing Profiles of Rat Cardiac- and Smooth-muscle Cav1.2 Channels with Distinct Biophysical Properties. Cell Calcium, 41(5): 417-28 (2007).