个人简介：

江南捕鱼（中国官网）有限公司,医学院助理教授、博士生导师。2014年本科毕业于山东大学生命科学学院，2019年博士毕业于清华大学生命科学学院，导师颜宁院士。随后在西湖大学生命科学学院进行博士后研究，导师施一公院士。2021年11月加入江南捕鱼（中国官网）有限公司,医学院组建研究课题组。自从事科研工作以来，已经以第一作者身份发表14篇高水平论文，其中含5篇顶级期刊Nature、Science。

教育背景：

2010年9月-2014年7月，山东大学，学士学位

2014年9月-2019年7月，清华大学，博士学位

工作经历：

2019年7月-2021年11月，西湖大学博士后

2021年11月至今，江南捕鱼（中国官网）有限公司,医学院助理教授

获奖情况及荣誉：

获得2019年度中国医学重大进展荣誉（药学部）

获得2020年度中国重要医学进展荣誉（新冠肺炎防治）

入选2020年中国博士后创新人才支持计划、博士后面上基金

获2020年全国博新计划十大创新成果

获得2020年浙江省自然科学奖一等奖（第二完成人）

获得2021年浙江省优秀博士后

获得2021年浙江省高校优秀共产党员

研究领域：

主要研究方向为结合结构生物学、分子生物学和生物化学方法深入解析人类重大疾病相关膜蛋白复合物的作用机制。

发表论文：

1. Yaning Li*, Qing Fan*, Bing Zhou*, Yaping Shen*, Yuanyuan Zhang*, Lin Cheng*, Furong Qi*, Shuo Song*, Yingying Guo*,Renhong Yan†, Bin Ju†, Zheng Zhang†. (2022). "Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants." iScience 25(6): 104431. (* indicates co-first authors; † indicates co-corresponding authors)

2. Yuanyuan Zhang* , Renhong Yan†, Qiang Zhou†. (2022). "ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications." Curr Opin Struct Biol 74: 102388. (* indicates co-first authors; † indicates co-corresponding authors)

3. RenhongYan*†, Pingping Cao*, Wenqi Song*, Yaning Li*, Tongtong Wang, Hongwu Qian, Chuangye Yan†, Nieng Yan†. (2021). Structural basis for sterol sensing by Scap and Insig. Cell Reports. (* indicates co-first authors; † indicates co-corresponding authors)

4. Renhong Yan*, Pingping Cao*, Wenqi Song*, Hongwu Qian, Ximing Du, Hudson W. Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J. Brown, Qiang Zhou, Chuangye Yan, Nieng Yan (2021). A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. (*indicates co-first authors)

5. Renhong Yan*, Yaning Li*,Jennifer Müller*, Yuanyuan Zhang*, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou. (2021). Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discovery. (* indicates co-first authors)

6. Liang Guo*, Wenwen Bi*, Xinling Wang*, Wei Xu*, Renhong Yan*, Yuanyuan Zhang*, Kai Zhao, Yaning Li, Mingfeng Zhang, Xia Cai, Shibo Jiang, Youhua Xie, Qiang Zhou, Lu Lu, Bobo Dang.(2021). Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection. Cell Research31, 98-100. (* indicates co-first authors)

7. Renhong Yan*, Ruoke Wang*, Bin Ju*, Jinfang Yu*, Yuanyuan Zhang*, Nan Liu*, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, YapingShen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia, Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang†, Linqi Zhang†, and Qiang Zhou†. (2021) Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Research. (* indicates co-first authors; † indicates co-corresponding authors)

8. Renhong Yan*†, Yuanyuan Zhang*, Yaning Li*, Fangfei Ye, Yingying Guo, Lu Xia, Xinyue Zhong, Ximin Chi, and Qiang Zhou†. (2021) Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2. Cell Research. (*indicates co-first authors; † indicates co-corresponding authors)

9. Yuning Chen*, Yanan Zhang*, Renhong Yan*, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang, Yaning Li, Jianxia Ou, Wendi Chu, Zhijuan Liang, Yongmei Wang, Yi-Li Chen, Ganjun Chen, Qi Wang, Qiang Zhou†, Bo Zhang†, and Chunhe Wang†(2021). ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduct Tar 6, 315. (* indicates co-first authors)

10. Renhong Yan, Yuanyuan Zhang, Yaning Li, Lu Xia, Yingying Guo, Qiang Zhou (2020). Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science367, 1444-1448. (First author) 

11. Xiangyang Chi*, Renhong Yan*, Jun Zhang*, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang. Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, Lu Xia, Ling Fu, Lihua Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen (2020). A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science369, 650-655. (* indicates co-first authors)

12. Renhong Yan*, Yaning Li*, Yi Shi*, Jiayao Zhou, Jianlin Lei, Jing Huang, Qiang Zhou (2020). Cryo-EM structure of the human heteromeric amino acid transporter b^0,+AT-rBAT. Science Advances6, eaay6379. (* indicates co-first authors)

13. Hongwu Qian*, Xin Zhao*, Renhong Yan*, Xia Yao, Shuai Gao, Xue Sun, Ximing Du,Hongyuan Yang, Catherine C. L. Wong, Nieng Yan. (2020). Structural basis for catalysis and substrate specificity of human ACAT1.Nature 581, 333-338. (* indicates co-first authors)

14. Renhong Yan*, Jiayao Zhou*, Yaning Li*, Jianlin Lei, Qiang Zhou. (2020). Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex. Cell Discovery6. (* indicates co-first authors)

15. Renhong Yan*, Xin Zhao*, Jianlin Lei, Qiang Zhou. (2019). Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex. Nature568, 127-130. (* indicates co-first authors)

16. Renhong Yan*, Hongwu Qian*, Ivan Lukmantara, Mingming Gao,Ximing Du, Nieng Yan, Hongyuan Yang. (2018). Human SEIPIN Binds Anionic Phospholipids. Dev Cell47, 248-256 e244. (* indicates co-first authors)