个人简介：

曹阳坡，江南捕鱼（中国官网）有限公司,医学院药理系副教授，博士生导师。2020年毕业于北京大学，获理学博士学位。2020年至2023年在美国哈佛医学院波士顿儿童医院从事心血管研究工作，2023年6月加入江南捕鱼（中国官网）有限公司,医学院药理学系。以第一作者（含共同）在Circulation、Circulation Research、PNAS、Dev Cell、Cardiovasc Res.等主流杂志发表多篇论文。主要从事心脏发育与疾病的转录调控研究，结合分子生物学，细胞生物学，表观遗传学等手段研究心脏生理及病理生理（心肌肥厚，心衰，房颤等）的发病机制及治疗靶点的开发。

教育背景：

2009年9月-2014年6月  西北农林科技大学，农学，学士

2014年9月-2020年1月  北京大学，病理生理学，博士

工作经历：

2020年1月-2023年3月   哈佛医学院波士顿儿童医院，博士后

2023年6月- 至今            江南捕鱼（中国官网）有限公司,医学院，助理教授

获奖情况及荣誉：

2018年 北京大学学术创新奖

2019年 北京大学基础医学院学术新锐一等奖

2020年 北京市优秀毕业生

2020年 北京大学优秀毕业生

2020年 北京大学优秀博士学位论文

研究领域：

1. 心肌细胞命运调控的表观遗传学机制

2. 线粒体质量控制与心脏病理生理

3. 高通量的基因及非编码区功能解析技术的开发

发表论文：

(#共同一作, *共同通讯)

1. Sweat ME#, Cao Y#, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv [Preprint]. 2023 Apr 22:2023.04.21.537535  (revision in Nature Cardiovascular Research) 

2. Guo Y#, Cao Y#, Jardin BD#, Mazumdar N, Guo C, Yang L, Lin J, Zhan C, Ma Q, Zhao M, Dong E, Pu WT. A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation. Sci China Life Sci (accepted)

3. Zhou P#, VanDusen NJ#, Zhang Y#, Cao Y#, Sethi I, Hu R, Zhang S, Wang G, Ye L, Mazumdar N, Chen J, Zhang X, Guo Y, Li B, Ma Q, Lee JY, Gu W, Yuan GC, Ren B, Chen K*, Pu WT*. Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation. Dev Cell. 2023 May 22;58(10):898-914.e7

4. Cao Y#, Zhang X#, Akerberg BN#, Yuan H, Sakamoto T, Xiao F, VanDusen NJ, Zhou P, Sweat ME, Wang Y, Prondzynski M, Chen J, Zhang Y, Wang P, Kelly DP, Pu WT. In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity. Circulation. 2023 Mar 14;147(11):881-896

5. Zhou P#, Zhang Y#, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT. GATA4 Regulates Developing Endocardium Through Interaction With ETS1. Circ Res. 2022 Nov 11;131(11):e152-e168

6. Liu R, Xu C, Zhang W, Cao Y, Ye J, Li B, Jia S, Weng L, Liu Y, Liu L, Zheng M. FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia. Cell Death Dis. 2022 Jul 21;13(7):634

7. Guo Y#, Cao Y#, Jardin BD#, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2023 Mar 17;119(1):221-235

8. Xu C, Cao Y, Liu R, Liu L, Zhang W, Fang X, Jia S, Ye J, Liu Y, Weng L, Qiao X, Li B, Zheng M. Mitophagy-regulated mitochondrial health strongly protects the heart against cardiac dysfunction after acute myocardial infarction. J Cell Mol Med. 2022 Feb;26(4):1315-1326

9. Li B, Ye J, Liu R, Weng L, Cao Y, Jia S, Xu C, Liu Y, Yan S, Zheng M. Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2. Life Sci. 2021 Nov 15;285:119918

10. Guo Y#, Cao Y#, Jardin BD#, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, Pu WT. Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008861118

11. Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang C, Liu R, Weng L, Liu Y, Liu L, Zheng M. Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction. Circ Res. 2019 Sep 27;125(8):728-743. doi: 10.1161/CIRCRESAHA.119.315432

12. Hu H, Jiang M, Cao Y, Zhang Z, Jiang B, Tian F, Feng J, Dou Y, Gorospe M, Zheng M, Zheng L, Yang Z, Wang W. HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. Cardiovasc Res. 2020 Apr 1;116(5):944-955

13. Cao YP, Zheng M. Mitochondrial dynamics and inter-mitochondrial communication in the heart. Arch Biochem Biophys. 2019 Mar 15;663:214-219

14. Ye J, Zheng Q, Jia S, Qiao X, Cao Y, Xu C, Weng L, Zhao L, Chen Y, Liu J, Wang T, Cheng H, Zheng M. Programmed Cell Death 5 Provides Negative Feedback on Cardiac Hypertrophy Through the Stabilization of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2a Protein. Hypertension. 2018 Oct;72(4):889-901

15. Weng L, Jia S, Xu C, Ye J, Cao Y, Liu Y, Zheng M. Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca2+ leakage channel Sec61α in mouse hearts. Cell Death Dis. 2018 May 23;9(6):612

16. Zhang CL, Chen ZJ, Feng H, Zhao Q, Cao YP, Li L, Wang JY, Zhang Y, Wu LL. C1q/tumor necrosis factor-related protein-3 enhances the contractility of cardiomyocyte by increasing calcium sensitivity. Cell Calcium. 2017 Sep;66:90-97

17. Qiao X, Jia S, Ye J, Fang X, Zhang C, Cao Y, Xu C, Zhao L, Zhu Y, Wang L, Zheng M. PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction. Sci Rep. 2017 Mar 27;7:45379

18. Jia S, Qiao X, Ye J, Fang X, Xu C, Cao Y, Zheng M. Nogo-C regulates cardiomyocyte apoptosis during mouse myocardial infarction. Cell Death Dis. 2016 Oct 20;7(10):e2432